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There is some evidence that an injection of local anaesthetic and steroid can help those who do not respond to the 4 Rs or have an underlying metabolic issue, but a simple injection will not correct the primary cause of the nerve compression

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In addition, probiotics can regulate the activity of immune cells, including T cells and macrophages, contributing to a balanced immune response that protects the BBB (Rastogi and Singh, 2022)

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Specifically, the leakage of electrons from mitochondrial ETC complexes gives rise to ROS, which can subsequently react with ferrous ions (Fe 2+ ) to generate OH radicals [89]

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