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The crystal structure of the acrylamide warhead containing inhibitor bound to JNK3 (PDB ID: 3V6S) showed that the pyridine ring of IN-8 is deeply buried in the ATP-pocket

However, all treatments carry risk

doi: 10.1371/journal.pone.0033657 18 Rodriguez-MoraSMateosEMoranMMartinMALopezJACalvoEet al

Phase 1/2 study of CPX-351 for patients with Int-2 or high risk International Prognostic Scoring System myelodysplastic syndromes and chronic myelomonocytic leukaemia after failure to hypomethylating agents