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2 Curcumin and its anticancer mechanisms and advantages Curcumin, the principal bioactive polyphenol derived from Curcuma longa , exerts multifaceted anticancer effects through the simultaneous modulation of critical oncogenic signaling pathways and epigenetic regulators [33, 34]

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After beating, samples were immediately placed on ice for 10 min and beating was repeated two more times prior to centrifuging at 15,000 g for 25 min at 4C