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10.1016/j.scitotenv.2004.01.019 27 HatfieldD.BerryM.GladyshevV

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The inhibition of sphingolipid biosynthesis disrupts numerous cell functions and signaling pathways, including apoptosis and mitosis, thus potentially contributing to carcinogenesis through an altered balance of cell death and replication [113]

Human OLs are however resistant to toxic effects of conditioned media from astrocytes preconditioned by immune cell supernatants, whereas immature OL lineage cells are susceptible to impaired differentiation and/or death 181