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Tiopronin is structurally similar to the GPx1 cofactor glutathione and was observed to align in a similar orientation to glutathione in the active site of GPx1 in the bovine model

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Mass Spectrometry Verification Mass spectrometry confirms molecular identity and structural accuracy

Beyond these established mechanisms, emerging, yet still limited, evidence suggests that glycine may also produce depolarizing effects via glycine-activated excitatory receptors (eGlyRs), including GluN1/GluN3-containing NMDA receptor assemblies that can be activated by glycine in a glutamate-independent manner