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2301-C E3 UBIQUITIN LIGASE NEDD4 IS A KEY NEGATIVE REGULATOR FOR GSDMD-MEDIATED PYROPTOSIS IN NON-ALCOHOLIC STEATOSIS Rui Jin, Xiaoxiao Wang, Baiyi Liu, Zilong Wang, Yuyun Song, Xiaohe Li, Feng Liu and Huiying Rao, Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis Background: Pyroptosis mediated by GSDMD is thought to be involved in NASH development, but the roles of GSDMD in the pathogenesis of NASH are not fully understood

The GSAAT activity in leaf extracts decreased by 30%, 10% and 40% in ntrc, trxf1 and ntrc/trxf1 , respectively, indicating a correlation between the decreases in plastidal reductants, GSAAT level and GSAAT enzymatic activity ( Figures 4E, F, H )

However, whether GHR functions as a control valve is still currently lacking in research

Disruption of Beclin-1 can alter cytokine production and immune cell function, impacting inflammatory conditions and infection defense