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Activation of NF- K B is responsible, among others, for stimulation of osteoclasts and increased activity of metalloproteinases, resulting in overproduction of lipid peroxides, oxidized proteins and inflammatory factors, and ultimately leading to oxidative damage of tissues

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An independent case-control cohort evaluated associations with schizophrenia diagnosis, while a cohort of 514 healthy adults assessed whether PRS-cognition associations are specific to schizophrenia