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Further, our use of the crosslinker EDCM 29 (as opposed to EDC 27 ) and subsequent UVAriboflavin crosslinking with optimized dose and exposure parameters, differentiates the present BPCDX from previous collagen-based hydrogels, imparting additional strength and resistance to degradation (see Supplementary Table 1 for full comparison of manufacturing parameters and material properties)

Real-world data shows how often people restart, but not whether a second course reaches the same low point