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Confusion with Growth Hormone and Secretagogues Growth hormone: Acts systemically Alters IGF-1 signaling Can downregulate receptors over time Growth hormone secretagogues: Stimulate pituitary GH release Rely on receptor activation Can lose effectiveness if overstimulated AOD-9604 does neither

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis Science 1995 270 : 286290 Brostjan C, Anrather J, Csizmadia V, Stroka D, Soares M, Bach FH, Winkler H