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[0385] The anti-ALPP/ALPPL2 antibodies described herein can be coupled directly to the radio-opaque moiety (e.g., at an available cysteine) or they can be attached to a "package" (e.g., a chelate, a liposome, a polymer microbead, a nanoparticle, etc.) carrying, containing, or comprising the radio-opaque material, e.g., as described below

In some cases, the exact cause is unknown

Minerals should be separated from certain medications: Take iron, calcium, or magnesium at least 4 hours apart from levothyroxine Separate these minerals from tetracycline or quinolone antibiotics by at least 2 hours Take fiber supplements at least 2 hours apart from oral medications Protein supplements can be consumed at any time but are particularly useful between meals or as meal replacements when appetite is poor

3 Mevalonate pathway