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No long-term safety trial exists for injectable use

Multiple clinical trials in photoaged skin (sun damage) have shown that topical GHK-Cu formulations improve skin appearance including reductions in fine lines and wrinkles, improvement in skin firmness and elasticity, enhancement of skin texture and smoothness, increase in skin thickness (reversing age-related dermal atrophy), improvement in skin clarity and reduction in hyperpigmentation, and overall rejuvenated appearance

Researchers synthesized the four-amino acid sequence Ala-Glu-Asp-Gly to create a stable, reproducible research compound that could be studied without relying on biological extracts

A: GHK-Cu is a naturally occurring peptide already present in human plasma, saliva, and urine