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Here, we describe the discovery, characterization and application of an ATP-grasp enzyme and ABS from the E-64 biosynthetic pathway (Fig

TB4 is found extracellularly in blood plasma and wound fluid, possibly regulating cell motility and angiogenesis by interacting with cell surface ATP synthase enzymes [26]

Moreover, other recent work indicates that the nigro-vagal pathway can modulate tone and motility of the proximal colon via D1-like receptors in the DMV, implying that the colon and small intestine, although both innervated by DMV, are regulated by distinct upstream inputs and receptor pathways 59