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For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine

4.1.4 Biodegradability and biocompatibility The choice of biomaterial is a crucial step in nanoparticle development, as the properties of biomaterials reflect not only physical characteristics but also their biodegradation and biocompatibility profiles, in which the suitable biomaterials should exhibit non-immunogenicity (Nunes et al., 2022

Significant differences between REF and GLI groups were observed for villus height, villus width, crypt depth, and villus height/crypt depth ratio (Fig