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Taken together, these in vivo data from multiple CRC models support our conclusion that inhibition of mitochondrial metabolism by metformin treatment can enhance the response of 5FU treatment by increasing tumour cell death and impeding tumour growth

Targeted overexpression of IGF1 in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury

It is widely understood that BC does not arise from a single genetic abnormality but rather involves a perturbation in a broad array of cell types, including cancerous cells, immune cells, epithelial cells, vascular cells, stromal cells, and hormones

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