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This was accompanied by upregulation of inducible nitric oxide synthase (iNOS), IL-1, and TNF-, and downregulation of arginase 1 (Arg-1), IL-10, and transforming growth factor-beta (TGF-)

doi:10.1016/j.phymed.2003.07.014 Dimitrova Z, Dimov B, Manolova N, Pancheva S, Ilieva D, Shishkov S

Holding therapy, for example, is a manipulative, body-based therapy that stems from the erroneous notion that autism is caused by a parents failure to bond with his or her child [12]