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Extrusion treatment has been shown to significantly increase the levels of PCs monomers and dimers present in grape seeds and skins

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Thus, in silico studies confirmed that Campesterol has a spasmolytic effect on bladder overactivity through muscarinic receptors, VGCC, KATP channels, and COX pathways

Hesperetin was also shown to alleviate TNBS-induced ulcerative colitis through antioxidant (increasing GSH and SOD while decreasing NO content), anti-inflammatory properties (reducing IL-6, TNF-, CD45 and NF-kB), antiapoptotic (diminishing caspase 3 and Bax expression) and through modulating JAk2/STAT3/SOCS3 [170,171]