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In ovarian cancer, three heterogeneous clusters (cluster 0, 3, and 4) emerged within HGSOC-1 and two clusters (cluster 1 and 2) in HGSOC-2 (Fig

It is worth mentioning that a recent study found that in tumors, the metabolite lactate affected the TME by regulating the lactylation of MOESIN in Tregs and enhancing TGF- signal transduction, thus promoting a new mechanism of tumorigenesis 266

There is limited clinical data published on intrathecal iron chelation in neurodegeneration, and no iron chelator is officially approved for IT use, given that this is a rather invasive experimental approach

When cMyc is overexpressed, it leads to coordinated changes in the expression of various gene families, which collectively enhance cellular growth and division