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Many do not, because the compound quality is unverified, the dose is based on internet research rather than clinical assessment, and there is no baseline, no follow-up, and no protocol adjustment based on individual response

Nearly one-third of tirzepatide participants achieved at least 25% total body weight loss, compared to 16% on semaglutide

Because these products are classified as cosmetics rather than medicines, they are not subject to the same regulatory scrutiny as licensed pharmaceutical treatments

While cagrilintide is not yet FDA-approved , its ongoing development suggests strong potential as part of a new pharmacologic framework in obesity care