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But the clinical trial data supports extending any step by 2 to 4 additional weeks if side effects remain problematic

Very frequent dosing (e.g., every 2 hours) can cause progressive attenuation due to acute tachyphylaxis [3]

Pros: Near 100% Bioavailability: By bypassing the liver and stomach, almost the entire dose reaches the bloodstream

Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice