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27,28 Opioid withdrawal, although very unpleasant and uncomfortable, is rarely life-threatening and is characterized by autonomic hyperactivity, and signs and symptoms which include anxiety, insomnia, nausea, vomiting, diarrhea, cramping, back pain, hot and cold flashes, and lacrimation

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For skin lightening purposes, dosages can range from 500 mg to 3,000 mg per day

This early BBB dysfunction and glymphatic system impairment may contribute to the initiation of neurodegenerative processes such as those seen in Alzheimer's disease (Sweeney et al., 2018)