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subtilis was found to further exhibit anti-aggregation properties by regulating the sphingolipid metabolic pathway involving upregulation of LAGR-1/CERS1 (ceramide synthase), ASM-3/SMPD1 (acid sphingomyelinase), and downregulation of SPTL-3/SPTLC2 (serine palmitoyltransferase), therefore, reducing glucosylceramide ( In PD and AD individuals, an increased abundance of Enterobacteriaceae taxa, particularly Escherichia coli , is associated with increased concentrations of LPS and the bacterial amyloid protein curli (Scheperjans et al., 2015

The Potential Molecular and Cellular Mechanism of Flavonoids for Iron Overload Based on the previous research results, we summarized the underlying mechanisms of flavonoids for treating iron overload according to the following three mechanisms: amelioration of iron status by various proteins and pathways, chelation of iron to reduce iron deposition, and resistance to oxidation to reduce iron overload-induced oxidative damage (Figure 3A)

Aldo-keto reductases are required for the reduction of aldehydes and ketones