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5 Disruption of the neuroendocrine network and the local biochemical microenvironment The pathological microenvironment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) involves not only inflammatory-immune crosstalk and oxidative stress, but alterations in local biochemical components and dysregulation of the neuroendocrine network also represent crucial links in the impairment of sperm development

As expected 32 , genetic variants within NR1H3 , but not NR1H2 (Extended Data Fig

Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation

The rising burden of IBD in Africa presents significant challenges, particularly in ensuring access to effective and affordable treatments