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Most peer-reviewed research literature studies the copper-bound form because GHK has high affinity for Cu(II) and the copper-bound complex is the bioactive form characterized in cellular research

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, and ONeill LA

Rice-Bran Products: Phytonutrients with Potential Applications in Preventive and Clinical Medicine

1e), allowed us to quantify all four possible products associated with direct ligation of both strands