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[4] Thus, the effectiveness of exogenously administered GSH is hindered by its instability when crossing cell membranes and its rapid hydrolysis in the circulation by gamma-glutamyltranspeptidase found on the extracellular surfaces of cells

Neurobiol Dis 31 (2), 198208

After adding the iPLA2 overexpression vector, the elevated lipid peroxidation was effectively reduced, and the ferroptosis of cells was inhibited at the same time