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Immunity 40 , 91104 (2014)

S., Orr A

which is particularly alarming since all antiretrovirals are used as part of drug mixtures, whereas a lot of studies on antiretroviral drugs toxicity in general report findings for individual drugs

While in many mammalian species UA is further degraded to allantoin, in humans and certain other primates the uricase activity responsible for this metabolic removal has been lost