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In recent years, there has been increasing evidence of the antitumor effects of metformin as an OXPHOS inhibitor and in a number of retrospective clinical trials, metformin has produced beneficial effects on survival outcomes in patients with NSCLC

*Correspondence: Varun Karamshetty [email protected] Present Address: Varun Karamshetty, INSEAD, Boulevard de Constance, Fontainebleau, France This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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