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Additionally, coagulation profiles (prothrombin time/INR) must be closely monitored, as worsening coagulopathy indicates declining hepatic synthetic function and may signal impending liver failure [30]

Study of schizophrenic patients and healthy controls in the Arab population from Syria found a strong association between C677T and schizophrenia, which showed higher variant T allele frequency in the patients group

Therefore, future clinical translation will probably benefit from biomarker-guided frameworks, incorporating (1) FSP1 abundance/localization, (2) CoQ pool size and redox state, (3) lipid peroxidation signatures and (4) metabolic context (mitochondrial activity and sulfur/selenium flux)