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485 DOX can chelate Fe 3+ to form a complex with Fe 2+ , which triggers excessive lipid peroxidation within mitochondria, resulting in mitochondria-dependent ferroptosis

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Although mouse and human XDH has some functional similarities, species differences in base/amino acid sequences and protein spatial conformation mean that innovative, highly selective small molecule inhibitors or small nucleic acid drugs designed against human XDH often face "acclimatization" issues in wild-type mice, resulting in significantly compromised binding affinity or efficacy