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Iannitelli AF, Segal A, Pare J-F, Mulvey B, Liles LC, Sloan SA, et al

We assessed 6,883,980 unique admissions (2,466,453 MA and 4,417,527 FFS) extracted from the CMS Integrated Data Repository for FFS claims, hospital-submitted MA claims, and Medicare Advantage Organization (MAO)-submitted MA inpatient encounter claims

L.OlsonD

Primarily, VNS increases the release of norepinephrine (NA), which inhibits NF-B activation, subsequently downregulating major histocompatibility complex class II (MHC-II) expression in astrocytes and suppressing the production of proinflammatory enzymes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) (9193)