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The FN III subunit features a binding domain known as FN III 12-14 , which contains positively charged amino acids, lysine, and arginine, facilitating interactions with multiple bioactive proteins, including TGF-, BMP-2, BMP-6, BMP-7, PDGF-BB, and HGF

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The observed decrease in GPx4 activity after TBI, along with these findings, suggests that the System Xc/GSH/GPX4 pathway plays an important role in the activation of ferroptosis following TBI (Figure 3D

Hematoma volume was calculated by summing the lesion areas of all sections and multiplying the total by the thickness of individual sections [31] (n = 4 per group)