MS (ES+) m/z 544.1.1H NMR (300 MHz, MeOD): H (ppm) 1.39 (s, 9H, BOC), 1.481.49 (m, 27H, 3xOtBu), 2.05 (t, 2H), 2.18 (m, 2H), 2.29 (m, 2H), 2.35 (t, 2H), 3.90 (dd, 1H,CH, 3J = 9.4 Hz, 3J = 4.27 Hz), 4.27 (dd, 1H,CH, 3J = 8.95 Hz, 3J = 5.29 Hz).13C NMR (75 MHz, MeOD):C (ppm) 26.48, 26.6, 27.1, 28.7, 30.43, 32.8, 52.97, 54.22, 79.87, 82.11, 156.58, 171.75, 173.1, 174.13
In a preferred embodiment of the invention, the CNS pathology is one of a neurodegenerative disorder, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), cerebrovascular accidents (CVA: ischemic stroke, intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH)), vascular-related dementia, brain trauma (traumatic brain injury), spinal cord injury, alcoholism, Prion diseases: Creutzfeldt-Jakob disease (CJD), bovine spongiform encephalopathy (BSE)
le N-(2-chloro-6-mthylphnyl)-2-[[[[(2-fluorophnyl)mthyl]amino]carbonyl]amino]-6-benzothiazolecarboxamide
Taking massive doses of poorly absorbed supplements can lead to digestive discomfort